Journal: PLOS Computational Biology

Article Title: NRV: An open framework for in silico evaluation of peripheral nerve electrical stimulation strategies

doi: 10.1371/journal.pcbi.1011826

Figure Lengend Snippet: Footprints and activation thresholds are evaluated using the FEniCS solver (orange line) and COMSOL Multiphysics (dashed blue line) with a LIFE ((a) and (c)) and a cuff-like electrode ((b) and (d)). The relative difference in electrode footprint estimation is plotted in a red dotted line. The nerve and the fascicle are 1000 μm and 800 μm in diameter respectively. The fascicle is surrounded by a 25 μm thick layer of perineurium, which corresponds to about 3% of the fascicle diameter . The nerve is plunged in a 10 mm large saline bath (not represented). The fascicle is made of anisotropic bulk endoneurium ( σ x = 0.57 S / m , σ y = 0.085 S / m ) and epineurium ( σ = 0.085 S / m ). Perineurium and saline conductivity are set to σ = 0.002/ m and σ = 2 S / m respectively [ , ].

Article Snippet: In addition, NRV does not depend on commercially licensed software such as MATLAB or COMSOL Multiphysics.

Techniques: Activation Assay, Saline